Enantioselective synthesis of 3,4-dihydroisoquinolin-1(2H)-ones by nickel-catalyzed denitrogenative annulation of 1,2,3-benzotriazin-4(3H)-ones with allenes.
نویسندگان
چکیده
A denitrogenative annulation reaction of 1,2,3-benzotriazin-4(3H)-ones with allenes catalyzed by a nickel-phosphine complex to produce a variety of substituted 3,4-dihydroisoquinolin-1(2H)-ones in a regioselective manner is described. A highly enantioselective version, as well as structural evidence for the mechanistic course of this reaction, is also presented.
منابع مشابه
SYNTHESIS OF SOME NEW 3-HETEROCYCLYL- 1,2,3-BENZOTRIAZIN-4(3H)-ONES
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 132 1 شماره
صفحات -
تاریخ انتشار 2010